反应详情

温度

60 °C

A suspension of N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide (5.64 g, 18.3 mmol) in acetic acid (20 mL) was heated at 60° C. After 30 min, the suspension became a solution and it was left overnight. The solvent was removed under reduced pressure and residue was triturated with DCM (10 mL) and filtered off. The precipitate was washed with DCM (3×10 mL) and dried to afford 4.76 g of the title compound (89%).

1. waitwas left overnight
2. customThe solvent was removed under reduced pressure and residue
3. customwas triturated with DCM (10 mL)
4. filtrationfiltered off
5. washThe precipitate was washed with DCM (3×10 mL)
6. customdried