HCID 68671161, compound → HCID 68670270, compound

Participants

Reaction Steps

To a solution of (S)-2-{-4-[4-fluoro-3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carbonyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (0.05 g, 0.10 mmol) in DCM (0.5 mL) 2M HCl in Et2O (2.0 mL) was added and the resulting suspension was stirred at room temperature overnight. The reaction was concentrated under reduced pressure then water (4.0 mL) was added and the mixture was concentrated again to afford 0.04 g of the title compound as chlorhydrate salt (86%).

Provenance & Evidence