Diethyl Ether → HCID 86647282, compound

Participants

Reaction Steps

To a solution of 4-{4-[3-(1H-Benzoimidazol-2-yl)-4-fluoro-phenyl]-piperazine-1-carbonyl}-piperidine-1-carboxylic acid tert-butyl ester (0.08 g, 0.16 mmol) in DCM (1 mL) 2M HCl in Et2O (3.0 mL) was added and the resulting suspension was stirred at room temperature for 3 days. The reaction was concentrated under reduced pressure, water (8 mL) was added and the solution was concentrated under reduced pressure. The solid was purified by preparative HPLC. HPLC fractions were neutralized with K2CO3 and concentrated. DCM (5 mL) and water (5 mL) were added, organic phase was separated and concentrated to give 44 mg of the title compound (72%).

Provenance & Evidence