反应详情

2-(3-bromophenyl)-1H-benzimidazole (7.8 g, 28.6 mmol) was completely dissolved in dry THF (300 ml), then NaH 60% m/m (1.49 g, 37.2 mmol) was added portionwise to the clear yellow solution. The light brown suspension was stirred 1 h rt, then CH3I (2.5 ml, 40.0 mmol) was added dropwise. The reaction mixture was stirred rt overnight. The reaction was quenched with H2O (300 ml), and extracted with EtOAc (2×450 ml). The organic extracts were dried over MgSO4, filtered and evaporated, to afford the compound as a brown-yellow solid (7.4 g, 70%).

1. stirringThe reaction mixture was stirred rt overnight
2. customThe reaction was quenched with H2O (300 ml)
3. extractionextracted with EtOAc (2×450 ml)
4. dry with materialThe organic extracts were dried over MgSO4
5. filtrationfiltered
6. customevaporated