Acetyl chloride → HCID 68671355, compound

Participants

Reaction Conditions

Reaction Steps

3-{4-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-[1,4]diazepane-1-carbonyl}-piperidine-1-carboxylic acid tert-butyl ester (0.21 g, 0.39 mmol) was dissolved in isopropanol (4 mL) and acetyl chloride (0.17 mL, 2.4 mmol) was added. Reaction was heated at 40° C. for 16 h then cooled to room temperature and concentrated under reduced pressure and dried at 60° C. to afford 0.19 g of the title compound as dichlorhydrate salt. (94%).

Provenance & Evidence