tert-Butyl piperazine-1-carboxylate → HCID 68671876, compound

HRID 2047413Notes

Reaction equation

HRID 2047413 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][CH:20]([C:23](O)=[O:24])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16].[C:26]([O:30][C:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31]([N:33]1[CH2:38][CH2:37][N:36]([C:23]([CH:20]2[CH2:21][CH2:22][N:17]([C:12]3[CH:13]=[CH:14][C:15]([Cl:16])=[C:10]([C:2]4[NH:3][C:4]5[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=5[N:1]=4)[CH:11]=3)[CH2:18][CH2:19]2)=[O:24])[CH2:35][CH2:34]1)=[O:32])([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 68671659HCID 68671659, compound

Product 1

HCID 68671876HCID 68671876, compound

Procedure

Synthesised as described in Method X-Step c starting from 1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidine-4-carboxylic acid (0.1 g, 0.28 mmol) and piperazine-1-carboxylic acid tert-butyl ester (0.06 g, 0.34 mmol). (72%)

Workup

  1. customSynthesised

Sources & evidence

ORD record
ord-06f832d6d57c4f3e938d61e96f3228dd
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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