反应详情

温度

40 °C

To a solution of the compound (11.3 g) obtained in step 3 in methanol (190 mL) was added 2N aqueous sodium hydroxide solution (79 mL), and the mixture was stirred at 40° C. for 2 hr. The mixture was concentrated, diluted with ethyl acetate, and neutralized with 1N hydrochloric acid. The separated aqueous layer was extracted with ethyl acetate. The combined organic layer was dried, and concentrated under reduced pressure to give the title compound (9.3 g, 91%) as a white powder.

1. concentrationThe mixture was concentrated
2. additiondiluted with ethyl acetate
3. extractionThe separated aqueous layer was extracted with ethyl acetate
4. customThe combined organic layer was dried
5. concentrationconcentrated under reduced pressure