benzyl 4-fluorotetrahydro-2H-pyran-4-carboxylate → 4-Fluorooxane-4-carboxylic acid

Participants

Reaction Steps

A mixture of the compound (0.18 g) obtained in step 2 and 20% palladium hydroxide (0.02 g) in ethanol/ethyl acetate (2/1 mL) was stirred under a hydrogen atmosphere (1 atm) at room temperature for 4 hr. The reaction mixture was filtered, and concentrated under reduced pressure. The residue was crystallized from ethyl acetate/hexane to give the title compound (0.084 g, 78%) as a gray powder.

Provenance & Evidence