Isopropanol hydrochloride → HCID 86655708, compound

HRID 2047483Notes

Reaction equation

[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([N:13]([CH3:37])[C:14]([N:16]([CH3:36])[C@@H:17]2[C@@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:40].CC(O)C>>[ClH:40].[F:12][C:9]([F:10])([F:11])[C:7]1[CH:6]=[C:5]([N:13]([CH3:37])[C:14]([N:16]([C@@H:17]2[C@@H:21]([C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[CH2:20][NH:19][CH2:18]2)[CH3:36])=[O:15])[CH:4]=[C:3]([C:2]([F:39])([F:1])[F:38])[CH:8]=1

Participants

Reactant 2

HCID 21912024Isopropanol hydrochloride

HCID 86655710HCID 86655710, compound

Product 1

HCID 86655708HCID 86655708, compoundYield 87%

Conditions

Temperature: 50 °C

Procedure

To the compound (0.30 g) obtained in Example 139 was added 2N hydrogen chloride/2-propanol (5 mL), and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (0.23 g, 87%) as a white powder.

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-5b92c8a845a947758bbb4670a2f1d5b1
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592454B2

Reaction notes

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