Isopropanol hydrochloride → HCID 86655714, compound

HRID 2047484Notes

Reaction equation

HRID 2047484 reaction equation
[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([N:13]([CH3:37])[C:14]([N:16]([CH3:36])[C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][N:23]=3)[CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:40].CC(O)C>>[ClH:40].[ClH:40].[F:39][C:2]([F:1])([F:38])[C:3]1[CH:4]=[C:5]([N:13]([CH3:37])[C:14]([N:16]([C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][N:23]=3)[CH2:20][NH:19][CH2:18]2)[CH3:36])=[O:15])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

3

Reactant 2

HCID 21912024Isopropanol hydrochlorideHCID 86655716HCID 86655716, compound

Product 1

HCID 86655714HCID 86655714, compound

Conditions

Temperature
50 °C

Procedure

A mixture of the compound (2.5 g) obtained in Example 190 and 2N hydrogen chloride/2-propanol (25 mL) was stirred at 45 to 55° C. for 4 hr, concentrated under reduced pressure and recrystallized from ethanol/IPE to give the title compound.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customrecrystallized from ethanol/IPE

Sources & evidence

ORD record
ord-690c5581df3b434eab8e120ed826ad29
Source dataset
uspto-grants-2013_11
Patent number
US08592454B2

Reaction notes

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