Isopropanol hydrochloride → HCID 86655800, compound

HRID 2047489Notes

Reaction equation

HRID 2047489 reaction equation
[F:1][C:2]([F:47])([F:46])[C:3]1[CH:4]=[C:5]([N:13]([CH3:45])[C:14]([N:16]([CH3:44])[C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29]([CH:31]3[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]3)=[O:30])[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:48].CC(O)C>>[ClH:48].[F:47][C:2]([F:1])([F:46])[C:3]1[CH:4]=[C:5]([N:13]([CH3:45])[C:14]([N:16]([C@H:17]2[C@H:21]([C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[CH2:20][N:19]([C:29]([CH:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)=[O:30])[CH2:18]2)[CH3:44])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1

Participants

3

Reactant 2

HCID 21912024Isopropanol hydrochlorideHCID 86655799HCID 86655799, compound

Product 1

HCID 86655800HCID 86655800, compoundYield 100%

Conditions

Temperature
45 °C

Procedure

A mixture of the compound (12 g) obtained in Example 303 and 2N hydrogen chloride/2-propanol (35 mL) was stirred at 45° C. for 3 hr, and concentrated under reduced pressure to give the title compound (11 g, 100%) as a white powder.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7952b54b0e314be8ab08761ab495b44a
Source dataset
uspto-grants-2013_11
Patent number
US08592454B2

Reaction notes

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