Thiomorpholine → HCID 86655866, compound

HRID 2047492Notes

Reaction equation

[F:1][C:2]([F:44])([F:43])[C:3]1[CH:4]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([CH3:41])[C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29](OC3C=CC([N+]([O-])=O)=CC=3)=[O:30])[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:45]1[CH2:50][CH2:49][S:48][CH2:47][CH2:46]1>>[F:1][C:2]([F:43])([F:44])[C:3]1[CH:4]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29]([N:45]3[CH2:50][CH2:49][S:48][CH2:47][CH2:46]3)=[O:30])[CH2:18]2)[CH3:41])=[O:15])[CH:6]=[C:7]([C:9]([F:11])([F:10])[F:12])[CH:8]=1

Participants

Reactant 2

HCID 67164Thiomorpholine

HCID 86655864HCID 86655864, compound

Product 1

HCID 86655866HCID 86655866, compound

Procedure

By reaction and purification in the same manner as in the method described in Example 420 and using the compound obtained in Example 362 and thiomorpholine, the title compound was obtained.

Workup

customBy reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-0ee5b00a0cf94b0aa9a90eb82c50020e
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592454B2

Reaction notes

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