4,4-Difluoropiperidine → HCID 86655867, compound

HRID 2047493Notes

Reaction equation

HRID 2047493 reaction equation
[F:1][C:2]([F:44])([F:43])[C:3]1[CH:4]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([CH3:41])[C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29](OC3C=CC([N+]([O-])=O)=CC=3)=[O:30])[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[F:45][C:46]1([F:52])[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]1>>[F:12][C:9]([F:10])([F:11])[C:7]1[CH:6]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29]([N:49]3[CH2:50][CH2:51][C:46]([F:52])([F:45])[CH2:47][CH2:48]3)=[O:30])[CH2:18]2)[CH3:41])=[O:15])[CH:4]=[C:3]([C:2]([F:1])([F:43])[F:44])[CH:8]=1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 86655864HCID 86655864, compound

Product 1

HCID 86655867HCID 86655867, compound

Procedure

By reaction and purification in the same manner as in the method described in Example 420 and using the compound obtained in Example 362 and 4,4-difluoropiperidine, the title compound was obtained.

Workup

  1. customBy reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-0d534b917a93439e9483f317f9181920
Source dataset
uspto-grants-2013_11
Patent number
US08592454B2

Reaction notes

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