HCID 86655714, compound → HCID 178502263, compound

HRID 2047496Notes

Reaction equation

HRID 2047496 reaction equation
Cl.Cl.[F:3][C:4]([F:34])([F:33])[C:5]1[CH:6]=[C:7]([N:15]([CH3:32])[C:16]([N:18]([C@H:20]2[C@H:24]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][N:26]=3)[CH2:23][NH:22][CH2:21]2)[CH3:19])=[O:17])[CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1.[CH3:35][O:36][C:37]([NH:39][C@H:40]1[CH2:45][CH2:44][C@H:43]([C:46](O)=[O:47])[CH2:42][CH2:41]1)=[O:38]>>[F:34][C:4]([F:3])([F:33])[C:5]1[CH:6]=[C:7]([N:15]([CH3:32])[C:16]([N:18]([CH3:19])[C@H:20]2[C@H:24]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][N:26]=3)[CH2:23][N:22]([C:46]([C@H:43]3[CH2:42][CH2:41][C@H:40]([NH:39][C:37](=[O:38])[O:36][CH3:35])[CH2:45][CH2:44]3)=[O:47])[CH2:21]2)=[O:17])[CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1

Participants

3

Reactant 2

HCID 86655714HCID 86655714, compoundHCID 178502264HCID 178502264, compound

Product 1

HCID 178502263HCID 178502263, compound

Procedure

By reaction and purification in the same manner as in the method described in Example 4 and using the compound obtained in Example 191 and trans-4-[(methoxycarbonyl)amino]cyclohexanecarboxylic acid, the title compound was obtained.

Workup

  1. customBy reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-5bfbed110d1144e0bb3b4d9f13351295
Source dataset
uspto-grants-2013_11
Patent number
US08592454B2

Reaction notes

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