HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-[(1S,2S)-1-(3,5-Difluorobenzyl)-2-((3R,6S)-6-ethoxymorpholin-3-yl)-2-hydroxyethyl]-acetamide trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-5-[(1S,2S)-2-Acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester | HCID 68558820 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[(1S,2S)-1-(3,5-Difluorobenzyl)-2-((3R,6S)-6-ethoxymorpholin-3-yl)-2-hydroxyethyl]-acetamide trifluoroacetate | HCID 68562026 | 97% |
Reaction Steps
Dissolve (R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester (0.060 g, 0.131 mmol) in dichloromethane (5 mL) and add trifluoroacetic acid (0.74 g, 6.5 mmol). Stir at room temperature for 1.5 hours and concentrate to give the title compound (60 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e5e384c1dfb1450e955e3e7c97087d8b |
| Source note | uspto-grants-2010_06 |