(Pyrimidin-5-yl)boronic acid → HCID 178423692, compound

HRID 2047546Notes

Reaction equation

HRID 2047546 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([C@H:9]3[CH2:12][C@H:11]([N:13]4[CH2:17]C[CH2:15][C@H:14]4[CH3:18])[CH2:10]3)[S:8][C:4]=2[CH:3]=1.[CH3:21][C:22]1[C:27](B2OC(C)(C)C(C)(C)O2)=[CH:26][CH:25]=[C:24]([CH3:37])[N:23]=1.N1C=C(B(O)O)C=NC=1>>[CH3:21][C:22]1[C:27]([C:2]2[CH:20]=[CH:19][C:5]3[N:6]=[C:7]([C@H:9]4[CH2:12][C@H:11]([N:13]([CH:14]([CH3:18])[CH3:15])[CH3:17])[CH2:10]4)[S:8][C:4]=3[CH:3]=2)=[CH:26][CH:25]=[C:24]([CH3:37])[N:23]=1

Participants

4

Reactant 3

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 219800342,6-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 178461421HCID 178461421, compound

Product 1

HCID 178423692HCID 178423692, compound

Procedure

The title compound was prepared according to the procedure described in Example 1F, except for substituting the product of Example 52A for the product of Example 1E and substituting the product of Example 2A for pyrimidine-5-boronic acid. MS: (M+H)+=366.

Sources & evidence

ORD record
ord-369fdeed17ed43569a8323df18932423
Source dataset
uspto-grants-2013_11
Patent number
US08592467B2

Reaction notes

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