HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-{(1S,2S)-1-(3,5-Difluorobenzyl)-2-[(3R,6R)-6-(3,3-dimethylbutoxy)-morpholin-3-yl]-2-hydroxyethyl}-acetamide trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,5R)-5-[(1S,2S)-2-Acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(3,3-dimethylbutoxy)-morpholine-4-carboxylic acid tert-butyl ester | HCID 68559571 | — |
| Product | N-{(1S,2S)-1-(3,5-Difluorobenzyl)-2-[(3R,6R)-6-(3,3-dimethylbutoxy)-morpholin-3-yl]-2-hydroxyethyl}-acetamide trifluoroacetate | HCID 68562971 | 98.8% |
Reaction Steps
Dissolve (2R,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(3,3-dimethylbutoxy)-morpholine-4-carboxylic acid tert-butyl ester (0.14 g, 0.27 mmol) in trifluoroacetic acid (2 mL) and stir 10 minutes. Concentrate to give the title compound. (0.14 g, 98.8% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-5f48760a722647089781555b9e96f770 |
| Source note | uspto-grants-2010_06 |