HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 4-chloro-7-fluoroquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 178469609 | — |
| Product | Ethyl 4-chloro-7-fluoroquinoline-3-carboxylate | HCID 14219731 | — |
Reaction Steps
Prepared as in Example 1b from ethyl 7-fluoro-4-hydroxyquinoline-3-carboxylate (Example 9c) and POCl3 as an off white solid (96%). MS 254, 256 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592592B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-09d75ae4ba3e41a6b521de3cea820807 |
| Source note | uspto-grants-2013_11 |