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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2047722Generated: November 1, 2026

Diethyl (ethoxymethylene)malonate → Ethyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

https://huagongshe.com/reaction/2047722

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
Reactant3-FluoroanilineHCID 9742—
ProductEthyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylateHCID 178469609—

Reaction Steps

Prepared as in Example 1c from 3-fluoroaniline and diethyl 2-(ethoxymethylene)malonate as a brown solid (51%). MS 236 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08592592B2
Source datasetuspto-grants-2013_11
ORD IDord-2163065147304fd681fd77b42aee87c6
Source noteuspto-grants-2013_11