HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-fluorobenzonitrile → 3-(3-amino-2-cyanophenoxy)-N-cyclopentyl-2,2-dimethylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-fluorobenzonitrile | HCID 522659 | — |
| Reactant | N-cyclopentyl-3-hydroxy-2,2-dimethylpropanamide | HCID 66746460 | — |
| Product | 3-(3-amino-2-cyanophenoxy)-N-cyclopentyl-2,2-dimethylpropanamide | HCID 66745906 | — |
Reaction Steps
Prepared as in Example 22b from N-cyclopentyl-3-hydroxy-2,2-dimethylpropanamide (Example 29c) and 2-amino-6-fluorobenzonitrile as a white solid (45%). 1H NMR (400 MHz, DMSO-d6) δ 1.19 (s, 6H), 1.40-1.49 (m, 4H), 1.61-1.63 (m, 2H), 1.74-1.79 (m, 2H), 3.95 (s, 2H), 4.03 (m, 1H), 5.98 (s, 2H), 6.19 (d, J=8.0 Hz, 1H), 6.33 (d, J=8.0 Hz, 1H), 7.17 (t, J=8.0 Hz, 1H), 7.23 (d, J=8.0 Hz, 1H). MS 302 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592592B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-96c94a1ca3064a7489eea41b726ac41b |
| Source note | uspto-grants-2013_11 |