Cyclopentylamine → N-cyclopentyl-3-hydroxy-2,2-dimethylpropanamide

HRID 2047760노트

반응식

HRID 2047760 반응식
[OH:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](O)=[O:5].[CH:9]1([NH2:14])[CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH:9]1([NH:14][C:4](=[O:5])[C:3]([CH3:8])([CH3:7])[CH2:2][OH:1])[CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

3

반응물 2

HCID 2906CyclopentylamineHCID 785483-Hydroxy-2,2-dimethylpropionic acid

생성물 1

HCID 66746460N-cyclopentyl-3-hydroxy-2,2-dimethylpropanamide

실험 절차

Prepared as in Example 24a from hydroxypivalic acid and cyclopentyl amine as an orange oil (32%). 1H NMR (400 MHz, DMSO-d6) δ 1.00 (s, 6H), 1.32-1.40 (m, 2H), 1.43-1.49 (m, 2H), 1.57-1.65 (m, 2H), 1.73-1.81 (m, 2H), 3.34 (d, J=4.0 Hz, 2H), 3.98 (m, 1H), 4.87 (t, J=4.0 Hz, 1H), 7.22 (d, J=4.0 Hz, 1H). MS 186 (MH+).

출처 및 근거

ORD 기록
ord-8c8efbabb24944eeb3fb968b0705cf06
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592592B2

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