HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-fluorobenzonitrile → 4-(3-amino-2-cyanophenoxy)-N-isopropylcyclohexanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-fluorobenzonitrile | HCID 522659 | — |
| Reactant | 4-hydroxy-N-isopropylcyclohexanecarboxamide | HCID 66746829 | — |
| Product | 4-(3-amino-2-cyanophenoxy)-N-isopropylcyclohexanecarboxamide | HCID 66745745 | — |
Reaction Steps
Prepared as in Example 22b from 4-hydroxy-N-isopropylcyclohexanecarboxamide (Example 45c) and 2-amino-6-fluorobenzonitrile as an off-white solid (17%). 1H NMR (400 MHz, DMSO-d6) δ 1.01 (d, J=6.4 Hz, 6H), 1.47-1.57 (m, 4H), 1.67-1.77 (m, 2H), 1.89-1.93 (m, 2H), 2.08-2.15 (m, 1H), 3.75-3.84 (m, 1H), 4.57 (brs, 1H), 5.93 (s, 2H), 6.19 (d, J=8.0 Hz, 1H), 6.28 (d, J=8.0 Hz, 1H), 7.13 (t, J=8.0 Hz, 1H), 7.48 (d, J=8.0 Hz, 1H). MS 302 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592592B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4669b027656a428580089be76bc661f6 |
| Source note | uspto-grants-2013_11 |