2-Amino-6-fluorobenzonitrile → HCID 66746052, compound

HRID 2047826Notes

Reaction equation

HRID 2047826 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13](F)[C:10]=1[C:11]#[N:12]>>[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:7][CH2:6][C@H:2]2[CH2:3][CH2:4][CH2:5][NH:1]2)[C:10]=1[C:11]#[N:12]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 2724541Prolinol, (R)-

Product 1

HCID 66746052HCID 66746052, compound

Procedure

Prepared as in Example 24d from (R)-pyrrolidin-2-ylmethanol and 2-amino-6-fluorobenzonitrile as brown solid (57%). MS 218 (MH+).

Sources & evidence

ORD record
ord-59b8227074164521bdb7389087c64ec9
Source dataset
uspto-grants-2013_11
Patent number
US08592592B2

Reaction notes

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