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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2047851Generated: October 25, 2026

Ethyl Acetoacetate → Ethyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylate

https://huagongshe.com/reaction/2047851

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetoacetateHCID 8868—
ReactantHCID 66747031HCID 66747031—
ProductEthyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylateHCID 66746012—

Reaction Steps

Prepared as in Example 2a from benzyl 3-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate (Example 110c) and ethyl 3-oxobutanoate as a yellow oil (21%). MS 344 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08592592B2
Source datasetuspto-grants-2013_11
ORD IDord-548369c3b8214bd081b3ad07b46a0ce7
Source noteuspto-grants-2013_11