HCID 66745949, compound → HCID 66746220, compound

HRID 2047857Notes

Reaction equation

HRID 2047857 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH2:25][C:26]([O:28]CC)=[O:27])=[N:8][C:9]2[C:14]([C:15]=1[NH2:16])=[C:13]([CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)[CH:12]=[CH:11][CH:10]=2)=[O:5])C>O>[NH2:16][C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:8]=[C:7]([CH2:25][C:26]([OH:28])=[O:27])[C:6]=1[C:4]([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 66745949HCID 66745949, compound

Product 1

HCID 66746220HCID 66746220, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared as in Example 1 from ethyl-4-amino-5-(2-cyclohexylethyl)-2-(2-ethoxy-2-oxoethyl)quinoline-3-carboxylate (Example 113a) as an orange solid (69%). 1H NMR (400 MHz, DMSO-d6) δ 0.89-0.92 (m, 2H), 1.14-1.29 (m, 4H), 1.44-1.49 (m, 2H), 1.56-1.66 (m, 4H), 1.73-1.76 (m, 1H), 3.15 (t, J=8.0 Hz, 2H), 3.70 (s, 2H), 7.09-7.11 (m, 1H), 7.38-7.42 (m, 1H), 7.46-7.51 (m, 2H). MS 338 (MH+-H2O).

Sources & evidence

ORD record
ord-156d2eb8bfc2487fa53654bc1c69717b
Source dataset
uspto-grants-2013_11
Patent number
US08592592B2

Reaction notes

Loading…