4-Chlorobutyldimethylphosphine oxide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

HRID 2048Notes

Reaction equation

[Na].[CH3:2][N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[NH:5][C:4]1=[O:14].ClCCC[CH2:19][P:20](=[O:23])([CH3:22])[CH3:21]>>[CH3:2][N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[N:5]([CH2:19][P:20](=[O:23])([CH3:22])[CH3:21])[C:4]1=[O:14]

Participants

Reactant 2

HCID 196891574-Chlorobutyldimethylphosphine oxide

HCID 66980828Theobromine sodium

Product 1

HCID 19689229[1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

Procedure

The title substance was prepared from 10.1 g (0.05 mol) of 3,7-dimethylxanthine sodium salt and 4-chlorobutyldimethylphosphine oxide analogously to Example 63.

Sources & evidence

ORD record: ord-b2bec745c38d43d2b05dd736598c1284
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728686

Reaction notes

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