Methanesulfonamide → HCID 58042386, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of methanesulfonamide (93.4 mg, 0.98 mmol) in THF (2 mL) at room temperature was added potassium tert-butoxide (119 mg, 1.06 mmol) in one portion with stirring under nitrogen for 15 minutes. 4-Methylphenyl-5-chloro-4-[(5-chloro-6-isopropoxypyridin-3-yl)thio]-2-fluorobenzoate (Preparation 224, 352 mg, 0.75 mmol) was added as a solution in THF (2 mL). The mixture was then heated at 60° C. for 3 hours and then left at room temperature for 18 hours. The solvent was concentrated in vacuo and the residue was partitioned between EtOAc (10 mL) and water (5 mL). The organic layer was separated and then washed with 1M NaOH (5 mL), 2M HCl (5 mL), saturated aqueous brine (5 mL), dried over MgSO4 filtered and evaporated. The residue was triturated with acetone/heptane (1:9) to afford a white solid which was filtered and washed with heptane to yield the title compound (45 mg, 13%) as a white solid.

Provenance & Evidence