Hydrochloric Acid → 4-({5-Chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoic acid

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tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate (Preparation 7, 0.400 g, 0.87 mmol) was dissolved in THF (5.0 mL) and methanol (5.0 mL). Then an aqueous solution of sodium hydroxide was added (3.0 M, 5.0 mL) and the mixture was stirred at room temperature under nitrogen for 3 hours. Aqueous solution of HCl (1.0 M, 75.0 mL) was added and the mixture was extracted with EtOAc (100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by reverse phase preparative HPLC (trilution method) to afford the title compound (0.31 g, 88%):

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