Hydrogen Peroxide → 4-[(5-Chloro-6-isobutoxypyridin-3-yl)oxy]benzamide

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Reaction Steps

4-[(5-chloro-6-isobutoxypyridin-3-yl)oxy]benzonitrile (Preparation 32, 162 mg, 0.535 mmol) and potassium carbonate (150 mg, 1.085 mmol) were suspended in DMSO (3 mL). Hydrogen peroxide aqueous solution (0.250 mL, 8.08 mmol) was added dropwise (exothermic reaction) and the mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with EtOAc (15 mL) and washed with water (2×15 mL). The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to yield a white solid which was triturated in DCM to yield the title compound. The filtrate was concentrated in vacuo and residue treated again triturated with DCM to yield a second crop of the title compound as a white solid (2 crops combined 85.0 mg, 49%):

Provenance & Evidence