HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2048086Generated: October 31, 2026
Cyclopropylboronic acid → HCID 58042362, compound
https://huagongshe.com/reaction/2048086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | 2-broMo-3-(difluoroMethoxy)pyridine | HCID 58042448 | — |
| Product | HCID 58042362 | HCID 58042362 | 58% |
Reaction Steps
Prepared according to Preparation 48 using 3-difluoromethoxy-2-bromopyridine (Preparation 217) and cyclopropylboronic acid. The reaction was heated to 95° C. for 18 hours before cooling to room temperature and filtering through arbocel. The filtrate was concentrated in vacuo and purified using silica gel column chromatography eluting with ethylacetate:heptane 1:5 to furnish the title compound as a colourless oil (273 mg, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592629B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-79a046edaf4f4bf7a1ebb93ad6927f28 |
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| Source note | uspto-grants-2013_11 |
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