HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolinimidohydrazide → tert-butyl 4-[[(Z)-[amino(pyridin-2-yl)methylidene]amino]carbamoyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolinimidohydrazide | HCID 70493 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-butyl 4-[[(Z)-[amino(pyridin-2-yl)methylidene]amino]carbamoyl]piperidine-1-carboxylate | HCID 87242610 | — |
Reaction Steps
To as solution of 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 37 g (167 mM) in dichloromethane (300 ml) is added carbonyl diimidazole (1 eq.) in small portion over a period of 30 min. pyridine-2-carbohydrazonamide is then added to reaction mixture and stirred at room temperature for 3 hrs. Dichloromethane is evauporated and reaction mass is then stirred in water for 30 min. solid precipitated is filtered and dried to afford the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592591B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-dad7e00269a64eb1b53e22cce4d44df8 |
| Source note | uspto-grants-2013_11 |