Pyridine-2-carbonitrile → HCID 178420047, compound

Participants

Reaction Steps

0.14 ml triethylamine is added to a solution of 156 mg 4-(3-phenylimidazo[1,2-a]pyrimidin-2-yl)benzaldehyde in 10 ml methanol. To this solution a solution of 140 mg 2-(5-Piperidin-1,2,4]triazol-3-yl)-pyridine*2HCl (Intermediate A prepared from tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate and pyridine-2-carbonitrile according to a procedure described in U.S. Pat. No. 4,011,218 or WO2005100344) is added, followed by 0.07 ml glacial acetic acid and 198 mg NaBH(OAc)3. The resulting mixture is stirred at room temperature. Three additional portions of 198 mg NaBH(OAc)3 are added after 2, 4 and 20 hours. The solvens is removed by evaporation after 24 h and the residue purified by chromatography on silica gel (dichlormethan/methanol).

Provenance & Evidence