Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Amino-5-bromopyrimidine | HCID 231310 | — |
| Reactant | HCID 53434504 | HCID 53434504 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86631777 | HCID 86631777 | — |
Reaction Steps
0.15 g (0.5 mM) of 4-[bromo(phenyl)acetyl]benzaldehyde and 2.0 equivalents of 5-bromopyrimidin-2-amine are dissolved in 6 ml DMF. The reaction mixture is heated at 90° C. overnight. The reaction mixture is cooled and water is added. It is then extracted with ethyl acetate. The organic layer is dried and concentrated. The crude product is purified by column chromatography to obtain the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08592591B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-fdcd2219034940ac992d000ecceb33b3 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
