Acetic Acid → HCID 178420049, compound

Participants

Reaction Steps

To a solution of 0.340 g (1.137 mM) of 4-(3-phenylimidazo[1,2-a]pyrimidin-2-yl)benzaldehyde in 7 mL of THF is added triethylamine (2 eq). The reaction mixture is stirred for 5 minutes. To this solution is added 4-[5-(1,3-thiazol-2-yl)-1H-1,2,4-triazol-3-yl]piperidine dihydrochloride (Intermediate G) (1.5 eq) followed by acetic acid (2.5 eq). The reaction mixture is stirred for 10 minutes. To this mixture is added NaBH(OAc)3 (6 eq) over a period of 60 minutes. The reaction mixture is stirred overnight. The reaction mixture is quenched with methanol and concentrated. The residue obtained is taken up in chloroform and washed with water, dried and concentrated. The crude is purified on a flash column chromatography to obtain the desired compound.

Provenance & Evidence