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HRID 2048233作成日：2026年10月25日
Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate → 4'-{[4-(2-Methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrile
https://huagongshe.com/reaction/2048233
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate | HCID 10020734 | — |
| 反応物 | HCID 178495283 | HCID 178495283 | — |
| 生成物 | 4'-{[4-(2-Methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrile | HCID 67009196 | 58.8% |
反応手順
A mixture of ethyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate (1.84 g) and N-(2-methoxy-1-methylethyl)-5-methyl-4H-1,2,4-triazol-3-amine (0.4 g) was stirred at 250° C. for 15 min under microwave irradiation. The obtained reaction mixture was purified by silica gel column chromatography to give the title compound as a colorless solid (0.63 g, 52%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08592431B2 |
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| 出典データセット | uspto-grants-2013_11 |
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| ORD ID | ord-1944ed8e4dfb460a876bdbe28c5a4724 |
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| 出典メモ | uspto-grants-2013_11 |
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