HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → (+)-4-(2'-Methylbutyl)phenyl 2-chloro-4-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Boric Acid | HCID 7628 | — |
| Reactant | 2-Chloro-4-hydroxybenzoic acid | HCID 91821 | — |
| Reactant | (+)4-(2'-Methylbutyl)phenol | HCID 22137140 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (+)-4-(2'-Methylbutyl)phenyl 2-chloro-4-hydroxybenzoate | HCID 20439632 | — |
Reaction Steps
This esterficiation may be carried out by the method described by Lowrance (Tet. Lett. 1971, 3453). The reactants (2-chloro-4-hydroxybenzoic acid and (+)4-(2'-methylbutyl)phenol in equimolar amounts) are dissolved in toluene and heated in a Dean and Stark apparatus together with catalytic amounts of sulphuric acid and boric acid. After crystallisation from ethanol/water, the product has the m.p. 142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195916 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-8cb624d8ecf341c2b592a435a7dc4629 |
| Source note | uspto-grants-1980_04 |