2-Fluorobenzoyl chloride → 3-(o-Fluorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

HRID 2048988Notes

Reaction equation

HRID 2048988 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:13][CH:12]2[CH2:11][NH:10][CH2:9]3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>>[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([N:10]1[CH2:11][CH:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)([CH2:13]2)[CH2:9]1)=[O:24]

Participants

4

Reactant 3

HCID 98082-Fluorobenzoyl chlorideHCID 10340Sodium CarbonateHCID 101303311-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

Product 1

HCID 204683333-(o-Fluorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

Procedure

A sample of 19.53 g of 1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane, 10.59 g of sodium carbonate and 15.8 g of o-fluorobenzoyl chloride are reacted to give the prodct 3-(o-fluorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as a brown gum.

Sources & evidence

ORD record
ord-66aeefab2e504f6d85d373fc567be10c
Source dataset
uspto-grants-1980_04
Patent number
US04196120

Reaction notes

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