HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 2-Acetylthiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Thiophene | HCID 8030 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-Acetylthiophene | HCID 6920 | — |
| Product | thiophene oxide | HCID 9548690 | — |
Reaction Steps
Acetylation of thiophene by acetyl chloride or acetic anhydride in the presence of various catalysts (U.S. Pat. No. 2,458,514) to obtain acetylthiophene or aceto-2 thienone or thienyl-2 methylketone and conversion of this methylketone into thienyl-2 acetamide or thienyl-2 thioacetamide by a WILLGERODT reaction, then hydrolysis of the amide (German Pat. No. 832 755).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04196299 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-7bc13d07a2b84d12ac5a77e02c602428 |
| Source note | uspto-grants-1980_04 |