1-Benzyl-3-aminopyrrolidine → HCID 20344834, compound

HRID 2049196Notes

Reaction equation

HRID 2049196 reaction equation
[Cl:1][C:2]1[C:3]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:18][CH:19]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:20]1>>[CH2:24]([N:21]1[CH2:22][CH2:23][CH:19]([NH:18][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Cl:1])[C:3]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:4][C:5]=2[O:11][CH3:12])[CH2:20]1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 27566131-Benzyl-3-aminopyrrolidineHCID 20344795HCID 20344795, compound

Product 1

HCID 20344834HCID 20344834, compound

Procedure

Following the procedure set forth in general method A supra using 1.29 g. of 5-chloro-4-diethylamino-2-methoxybenzoic acid and 0.97 g. of 3-amino-1-benzylpyrrolidine, 0.93 g. of oily N-(1-benzyl-3-pyrrolidinyl)-5-chloro-4-diethylamino-2-methoxybenzamide was obtained (purified by a silica gel column chromatography using a mixture of chloroform, ether and methanol (volume ratio 5:2:1) as an eluting solution).

Sources & evidence

ORD record
ord-a4f1cf821a564d44a676983011209c92
Source dataset
uspto-grants-1980_04
Patent number
US04197243

Reaction notes

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