1-Benzyl-3-aminopyrrolidine → HCID 20344825, compound

HRID 2049198Notes

Reaction equation

HRID 2049198 reaction equation
[Cl:1][C:2]1[C:3]([N:13]([CH2:15][CH3:16])[CH3:14])=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:17][CH:18]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:19]1>>[CH2:23]([N:20]1[CH2:21][CH2:22][CH:18]([NH:17][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Cl:1])[C:3]([N:13]([CH2:15][CH3:16])[CH3:14])=[CH:4][C:5]=2[O:11][CH3:12])[CH2:19]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27566131-Benzyl-3-aminopyrrolidineHCID 20344811HCID 20344811, compound

Product 1

HCID 20344825HCID 20344825, compound

Procedure

Following the procedure set forth in general method A supra using 1.22 g. of 5-chloro-4-(N-ethyl-N-methylamino)-2-methoxybenzoic acid and 0.97 g. of 3-amino-1-benzyl-pyrrolidine, 1.31 g. of N-(1-benzyl-3-pyrrolidinyl)-5-chloro-4-(N-ethyl-N-methylamino)-2-methoxybenzamide was obtained.

Sources & evidence

ORD record
ord-c646e6e16ebe45f9a16616e83cf7d4e5
Source dataset
uspto-grants-1980_04
Patent number
US04197243

Reaction notes

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