Malic Acid → 1,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

HRID 2049203Notes

Reaction equation

HRID 2049203 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1.[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37]>C(O)C>[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 525Malic AcidHCID 1531601,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone

Product 1

HCID 1317117371,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 134 mg. of DL-malic acid, and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-4de9e8f05c184e80a1d9f4dc3be18001
Source dataset
uspto-grants-1980_04
Patent number
US04197249

Reaction notes

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