Lactic Acid → 1,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone dilactate salt

HRID 2049204Notes

Reaction equation

HRID 2049204 reaction equation
[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1.[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].C(O)C>CC(C)=O>[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 612Lactic AcidHCID 702EthanolHCID 4330601,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

Product 1

HCID 1317117381,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone dilactate salt

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 120 mg. of 80% DL-lactic acid, and 10 ml. of ethanol is heated on a steam bath for 10 minutes, cooled, treated with 50 ml. of acetone and cooled to obtain the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperaturecooled
  3. additiontreated with 50 ml

Sources & evidence

ORD record
ord-f306f1010d944c88b8706d8865d11abb
Source dataset
uspto-grants-1980_04
Patent number
US04197249

Reaction notes

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