HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (-)-alpha-Amino-3-(bromomethyl)-4-hydroxybenzeneacetic acid hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Hydroxyphenylglycine | HCID 92143 | — |
| Product | (-)-alpha-Amino-3-(bromomethyl)-4-hydroxybenzeneacetic acid hydrobromide | HCID 70576814 | — |
Reaction Steps
To a solution of (-)-α-amino-4-hydroxybenzeneacetic acid (0.6 mole) in a minimum amount of concentrated hydrobromic acid at 35°-40° C. is added 50 ml of aqueous formaldehyde (35-37%) (0.6 mole). The addition of hydrogen bromide gas is begun. After 5-10 minutes, a solid begins to precipitate. Stirring is continued for 30 minutes. The title compound is collected and washed with ether and acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04197240 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-fa377f79406d40728fbafab9c9cba44d |
| Source note | uspto-grants-1980_04 |