HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanethiol → alpha-Amino-4-hydroxy-3-[(methylthio)methyl]benzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanethiol | HCID 878 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (-)-alpha-Amino-3-(chloromethyl)-4-hydroxybenzeneacetic acid hydrochloride | HCID 70578051 | — |
| Solvent | Water | HCID 962 | — |
| Product | alpha-Amino-4-hydroxy-3-[(methylthio)methyl]benzeneacetic acid | HCID 23329760 | — |
Reaction Steps
To a solution of methanethiol (3 g, 0.04 mmole) in 250 ml of water is added sodium hydroxide (0.04 mole) followed by (-)-α-amino-3-(chloromethyl)-4-hydroxybenzeneacetic acid hydrochloride (5 g, 0.02 mole). The solution obtained is stirred overnight. Removal of the solvent by flash evaporation gives a quantitative yield of the title compound combined with 2 equivalents of sodium chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04197240 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-6895e662a49547578a2e17d6e9039f19 |
| Source note | uspto-grants-1980_04 |