alpha-Amino-4-hydroxy-3-[(methylthio)methyl]benzeneacetic acid → (-)-alpha-Amino-4-hydroxy-3-[(methylsulfinyl)methyl]benzeneacetic acid
Reaction equation
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][S:14][CH3:15])[CH:7]=1)[C:3]([OH:5])=[O:4].I([O-])(=O)(=O)=[O:17].[Na+]>>[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][S:14]([CH3:15])=[O:17])[CH:7]=1)[C:3]([OH:5])=[O:4]Participants
3
Procedure
To an aqueous solution (500 ml) of α-amino-4-hydroxy-3-[(methylthio)methyl]benzeneacetic acid (1 mole) is added sodium metaperiodate (1 mole). The mixture is stirred at room temperature for 5 hours, it is filtered and the filtrate is lyophilized to give a quantitative yield of the title compound.
Workup
- filtrationit is filtered
Sources & evidence
- ORD record
- ord-e1532e3a8a2547259ecbf853e421080d
- Source dataset
- uspto-grants-1980_04
- Patent number
- US04197240
Reaction notes
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