HCID 70586926, compound → HCID 70588450, compound

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In like manner and using the appropriate quantities of reagents, substitution of α-(3-ethoxy-1-methyl-3-oxo-1-propen-1-yl)amino-3-[[(aminoiminomethyl)thio]methyl]-4-hydroxybenzeneacetic acid; α-(3-ethoxy-1-methyl-3-oxo-1-propen-1-yl)amino-3-[[(4,5-dihydro-1H-imidazol-2-yl)-thio]methyl]-4-hydroxybenzeneacetic acid; or α-(3-ethoxy-1-methyl-3-oxo-1-propen-1-yl)amino-4-hydroxy-3-[(methylthio)methyl]benzeneacetic acid in place of α-(3-ethoxy-1-methyl-3-oxo-1-propen-1-yl)amino-3-(azidomethyl)-4-hydroxybenzeneacetic acid gives the following respective compounds: 6-[[Amino[3-[[(aminoiminomethyl)thio]methyl]-4-hydroxyphenyl]acetyl]amino]3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-[[amino-3-[[[(4,5-dihydro-1H-imidazol-2-yl)thio]methyl]-4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; and 6-[[amino[4-hydroxy-3-[(methylthio)methyl]phenyl]acetyl]-amino]-3,3-dimethyl-7-oxo-5-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Provenance & Evidence