Dicyclohexylcarbodiimide → HCID 86736920, compound

Participants

Reaction Conditions

Reaction Steps

Equivalent amouts (0.05 mole) of the sodium salt of 4-hydroxy-3-(methoxymethyl)benzeneacetic acid and 6-amino-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic acid, ethyl ester, are added to dimethylformamide (DMF). The temperature is maintained at 0° C. Then about 1.2 equivalents of dicyclohexylcarbodiimide in DMF is added. The mixture is stirred at 0° C. for from 0.5 to 3 hours and an additional 2 to 5 hours at room temperature. Filtration of the reaction mixture removes the formed dicyclohexylurea. The filtrate is then diluted with chloroform, methylene chloride or ethyl acetate, washed with water, dried and evaporated to give the title compound.

Provenance & Evidence