Acetic Anhydride → HCID 70573520, compound

HRID 2049271Notes

Reaction equation

HRID 2049271 reaction equation
[O:1]=[C:2]([CH2:25][OH:26])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C@@H:9]1[C@@H:13](/[CH:14]=[CH:15]/[CH2:16][C:17]([OH:23])([CH3:22])[CH2:18][CH2:19][CH2:20][CH3:21])[CH:12]=[CH:11][C:10]1=[O:24].[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[O:1]=[C:2]([CH2:25][O:26][C:27](=[O:29])[CH3:28])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C@@H:9]1[C@@H:13](/[CH:14]=[CH:15]/[CH2:16][C:17]([OH:23])([CH3:22])[CH2:18][CH2:19][CH2:20][CH3:21])[CH:12]=[CH:11][C:10]1=[O:24]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 70567007HCID 70567007, compound

Product 1

HCID 70573520HCID 70573520, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.1 g of 1,9-dioxo-16-hydroxy-1-hydroxymethyl-16-methyl-10,13-trans-prostadiene in 0.75 ml of pyridine is added 0.026 g of acetic anhydride. After 18 hours at room temperature, the solvent is removed at reduced pressure and the residue is chromatographed on silica gel to give the title compound.

Workup

  1. customthe solvent is removed at reduced pressure
  2. customthe residue is chromatographed on silica gel

Sources & evidence

ORD record
ord-57a3f5cb3bac4ad5b8f7cb4842b0a02b
Source dataset
uspto-grants-1980_04
Patent number
US04197245

Reaction notes

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