反应详情

1-Bromo-1-phenyl-2-propanone (10.6 g, 0.050 mole), o-chlorothiobenzamide (8.8 g, 0.051 mole), and ethanol (100 ml) are mixed and, after the initial exothermic reaction has subsided, heated under reflux for two hours. The ethanol is evaporated and the residue is treated with chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and evaporated to leave a yellow oil which solidifies on standing. Recrystallization from acetonitrile yields 11.3 g (79%) of 2-(2-chlorophenyl)-4-methyl-5-phenylthiazole, m.p. 63°-65° C.

1. customafter the initial exothermic reaction
2. temperatureheated
3. temperatureunder reflux for two hours
4. customThe ethanol is evaporated
5. additionthe residue is treated with chloroform and aqueous sodium bicarbonate
6. customThe chloroform layer is separated
7. customevaporated
8. customto leave a yellow oil which
9. customRecrystallization from acetonitrile