Water → HCID 23350146, compound

Participants

Reaction Steps

To a two phase system containing 100 ml of water, 100 ml of toluene, 19.0 g (100 mmol) of potassium isopropyl trithiocarbonate and 50 mg of tetrabutyl ammonium bisulfate, a phase transfer catalyst, is added 6.3 ml (100 mmol) of chloroacetonitrile. The temperature of the reaction is maintained at between 20° and 30° C. After 4.5 hours the layers are separated and the toluene layer washed with water, brine, dried with Na2SO4, filtered, and concentrated in vacuo. The residue is distilled to give 11.4 g of isopropyl cyanomethyl trithiocarbonate as a yellow oil, boiling point 110°-113° C. at 0.1 mm Hg.

Provenance & Evidence